Fragile X

Fragile X Syndrome  

Fragile-X Syndrome is a genetic condition that causes a wide range of developmental problems including learning disabilities and mental retardation. It’s an inherited X-linked dominant pattern whereby a fragile area of the X chromosome tends to repeat bits of genetic code. Because boys have only one X chromosome, a single fragile X is more likely to affect them more severely. Affected males also tend to have notable physical characteristics that become more apparent with age. Twenty percent of boys with Fragile X will meet the full criteria for autism. Additionally, most boys and some girls will exhibit symptoms of autism.

Fragile X occurs in approximately 1 in 4,000 to 6,000 males and 1 in 8,000 to 9,000 females. 

In addition to learning difficulties, affected children tend to be restless and inattentive. Notable physical characteristics in boys will include a long and narrow face, large ears, prominent jaw, unusually flexible fingers, and enlarged testicles (macro-orchidism).

Fragile X Symptoms

• Attention deficits and hyperactivity

• Autistic behaviors and characteristics

• Large forehead and/or ears with a prominent jaw 

• Flat feet 

• Mental impairment, ranging from learning disabilities to mental retardation 

• Large testicles (macro-orchidism) 

• Tendency to avoid eye contact 

• Hyperextensible joints, especially fingers 

• Seizures (epilepsy affects approximately 25% of people with Fragile X) 

• Large size for age 

• High anxiety with unstable moods


Important Disclaimer

All information in this site is presented for support and educational purposes only. It is not intended to substitute for medical treatment or visiting a licensed medical physician.

Visitors who desire to apply or use any information listed herein are urged to consult with licensed healthcare professionals first. All information is deemed reliable but its accuracy can't be guaranteed.

Did You Know?

  • * In 1970, Autism affected 1 out of 10,000 children
  • * Autism now affects 1 out of 88 children
  • * Autism affects 1 in 54 boys
  • * 1.7 million Americans have some form of autism
  • * 4 out of 5 autistic children are boys

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